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MADRID Omer Toprak Jersey , May 1 (Xinhua) -- The city of Madrid is steeling itself for what could be the most important sporting event in the city's history, even though it will be played in the Portuguese capital, Lisbon.
Atletico Madrid's stunning 3-1 win away to Chelsea on Wednesday night set up a Madrid derby for the final of the Champions League on May 24.
It is the first time the two sides have even met in a European final and the game will see Real Madrid chase their 10th European Cup Nuri Sahin Jersey , while Atletico, who are playing their first Champions League final since 1974, seek to write their name on the trophy for the first time.
Should Atletico win in Lisbon Neven Subotic Jersey , that would make Madrid the first European city to have two teams that have conquered the most important trophy in the European game.
Both sides have been impressive en-route to the final with Real Madrid knocking out German trio, Schalke 04, Borussia Dortmund and Bayern Munich Mikel Merino Jersey , a run which culminated with their incredible 4-0 win in Munich on Wednesday.
Atletico have been no less impressive, beating Zenit St Petersburg, Porto and Chelsea on their way to the big game. While Real Madrid have used the pace of Cristiano Ronaldo Maximilian Philipp Jersey , Gareth Bale and Angel Di Maria to launch furious counter-attacks, Atletico have relied on playing as a unit, being hard to break down and then using the power of Diego Costa and the skill of Arda Turam to do the damage.
It will be a massive contrast in styles Matthias Ginter Jersey , and if previous meetings this season are anything to go by, possibly not the most open of games. Atletico and Real Madrid have played four times this campaign with Atletico winning once, Real twice (in the Copa del Rey) and one 2-2 draw.
The two league meetings saw exhibitions of subterranean football with foul Mario Gotze Jersey , dives and general bad-temper in all parts of the pitch and while things cooled down in the Kings Cup, due partly to Atletico looking tired, the signs are it will be a difficult final to referee.
That final is still three weeks away and both clubs will have to put it into the back of their minds until the end of the season as both are fighting for the BBVA Primera Liga title.
Atletico have a six point lead over their neighbors Marco Reus Jersey , who have a game in hand, and a four point advantage over Barcelona and could, in theory be Champions this Sunday if Real Madrid lose and Barca fail to win.
That is unlikely to happen Marcel Schmelzer Jersey , but it is just another topic to throw into the debate which will be held in every bar in the capital over the coming weeks and then in the exodus of fans to Lisbon.
For three weeks at least, forget Rio, because Madrid is the capital of the footballing world.
SAN FRANCISCO， March 22 (Xinhua) -- Researchers have found a small molecule that was able to block the production of a specific protein involved in low-density lipoprotein (LDL) turnover by stalling only the ribosome that produces that protein.
Reported in the journal PLOS Biology， the discovery of the chemical compound， which halted the production of a small set of proteins while leaving general protein production untouched， suggests a new drug search strategy: find compounds that target undesired proteins before they are even made.
Many of today's therapies for cancer or heart disease are monoclonal antibodies that bind and disable proteins outside the cell. The immunotherapeutic checkpoint inhibitors block suppressor proteins， unleashing the immune system to attack cancer. But they aren't effective against all proteins， can't enter cells and must be delivered via injection.
Ribosomes are large， general-purpose molecular machines that translate genetic instructions in the form of messenger RNA into the proteins used to build cells， the enzymes in charge of cellular housekeeping， and the hormones that carry messages in and between cells. While antibiotics are known to stall the ribosome， they halt production of most proteins， explained Jamie Cate， a University of California， Berkeley， professor of molecular and cell biology and of chemistry.
In the study by Cate and his colleagues at UC Berkeley and Pfizer Worldwide Research and Development， the small molecule， when delivered orally to rats， lowered LDL cholesterol levels， much the way statins do， though by a different mechanism: by lowering the production of the protein PCSK9， short for proprotein convertase subtilisin kexin 9. The chemical stalls the ribosome only when it's producing PCSK9 and a couple of dozen other proteins out of the tens of thousands of proteins the body produces， as shown by a relatively new technique called ribosomal profiling.
Knocking out PCSK9 is known to lower blood levels of LDL cholesterol， the so-called bad cholesterol， presumably lowering risk of cardiovascular disease.
"PCSK9 was just where we started. Now we can think about how to come up with other small molecules that hit proteins that nobody has been able to target before because， maybe， they have a floppy part， or they don' t have a nook or cranny where you can bind a small molecule to inhibit them，" Cate was quoted as saying in a news release from UC Berkeley. "This research is saying， we may be able to just prevent the synthesis of the protein in the first place."
Suspecting that the small molecule， a multi-ringed chlorinated compound， could serve as a template， like a key blank that can be machined to open a specific lock， Cate said "we now have this key blank that we can cut in a number of different ways to try to go after undruggable proteins in a number of different disease states."
The molecule was discovered by Pfizer labs through live-cell screening for compounds that lower production of the protein PCSK9， which regulates the recycling of the LDL receptor.
CHONGQING Marc Bartra Jersey , March 29 (Xinhua) -- Southwest China's Chongqing city will build a museum featuring history and objects related to weapon product.